MOTS-c: a peptide from the mitochondrion
Sequence, mitochondrial origin and research areas of the MOTS-c peptide — a neutral overview, with no claims.
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Identity card
- Class
- Mitochondrial-derived peptide (MDP)
- Sequence
- 16 aa — MRWQEMGYIFYPRKLR
- Formula
- C₁₀₁H₁₅₂N₂₈O₂₂S₂
- Molecular weight
- 2 174,6 g/mol
- CAS no.
- 1627580-64-6
- Discovery
- Encoded by the mitochondrial 12S rRNA (MT-RNR1 gene)
A peptide encoded by the mitochondrion
MOTS-c is a short 16-amino-acid peptide (sequence MRWQEMGYIFYPRKLR). Remarkably, it is encoded within the mitochondrial genome, inside the 12S ribosomal RNA — a region not previously known to produce peptides.
It belongs to the family of mitochondrial-derived peptides (MDPs).
A recent discovery
MDPs are a recently identified class; MOTS-c is among the most studied. Its production is reported to rise with physical exercise, which is why the literature describes it as an 'exercise mimetic'.
Research areas under study
In the literature, MOTS-c is studied around metabolism, notably glucose in skeletal muscle. Noting a research direction implies no established result or benefit. Educational content, with no human use.
Strictly educational and scientific content. No effect, benefit or human use is described. Products are intended solely for laboratory research (RUO): they are neither medicines nor food supplements. For any health question, consult a qualified professional.